Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver.

@article{Vos1998UpregulationOT,
  title={Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver.},
  author={Tineke Vos and Guido J E J Hooiveld and Henk Koning and S. Terry Childs and Dirk K. F. Meijer and Han Moshage and Petra Lynen Jansen and Michael M{\"u}ller},
  journal={Hepatology},
  year={1998},
  volume={28 6},
  pages={1637-44}
}
Endotoxin-induced cholestasis is mainly caused by an impaired canalicular secretion. Mrp2, the canalicular multispecific organic anion transporter, is strongly down-regulated in this situation, and canalicular bile salt secretion is also reduced. We hypothesized that other adenosine triphosphate-binding cassette (ABC) transporters may compensate for the decreased transport activity to protect the cell from cytokine-induced oxidative damage. Therefore, we examined the expression of ABC-transport… CONTINUE READING
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