Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.

@article{Ryan2012UpregulationOT,
  title={Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons.},
  author={Sean D. Ryan and Eric M. C. Britigan and Lauren M. Zasadil and Kristen Witte and Anjon Audhya and Avtar Roopra and Beth A. A. Weaver},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 33},
  pages={E2205-14}
}
The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and promotes tumors in mice [Iwanaga Y, et al. (2007) Cancer Res 67:160-166]. However, the prevalence and consequences of Mad1 overexpression are currently unclear. Here we show that Mad1 is frequently overexpressed in human cancers and that Mad1 up… CONTINUE READING
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