Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.

@article{Adamec2000UpregulationOT,
  title={Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.},
  author={Emil Adamec and Panaiyur S. Mohan and Anne M. Cataldo and Jean Paul G. Vonsattel and Ralph A. Nixon},
  journal={Neuroscience},
  year={2000},
  volume={100 3},
  pages={663-75}
}
Previous studies established that the populations of neurons that frequently degenerate in Alzheimer's disease exhibit robust up-regulation of the lysosomal system. In this study, we investigated alterations of the lysosomal system during different forms of experimental injury in rat hippocampal neurons in culture, utilizing a combination of immunocytochemical and biochemical methods. Using triple-label immnocytochemistry for activated caspase-3, fragmentation of DNA and the microtubule… CONTINUE READING
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