Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

@article{Bavoux2005UpregulationOT,
  title={Up-regulation of the error-prone DNA polymerase \{kappa\} promotes pleiotropic genetic alterations and tumorigenesis.},
  author={Clarisse Bavoux and A M Leopoldino and Val{\'e}rie Bergoglio and Jiyang O-Wang and Tomoo Ogi and Anne Bieth and Jean-Gabriel Judde and S{\'e}rgio D. Junho Pena and M Poupon and Thomas Helleday and Masatoshi Tagawa and Carlosrenato Machado and Jean-Sebastien Hoffmann and Christophe Cazaux},
  journal={Cancer research},
  year={2005},
  volume={65 1},
  pages={325-30}
}
It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more drastic upheaval of structure and organization of the genome. Genetic instability, as an operative force, will produce genetic variants and the greater the instability, the larger… CONTINUE READING

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