Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.

@article{Fujita2001UpregulationOT,
  title={Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas.},
  author={Manabu Fujita and Yoichi Furukawa and Toshiyuki Tsunoda and Tatsuo Tanaka and Michio Ogawa and Yusuke Nakamura},
  journal={Cancer research},
  year={2001},
  volume={61 21},
  pages={7722-6}
}
To clarify the molecular mechanisms of human carcinogenesis associated with abnormal Wnt/wingless signaling, we searched for genes the expression of which was significantly altered by introduction of wild-type AXIN1 into LoVo colon cancer cells. By means of a cDNA microarray, we compared expression profiles of LoVo cells infected with either adenoviruses expressing wild-type AXIN1 (Ad-Axin) or those expressing a control gene (Ad-LacZ). Among the genes showing altered expression, the ectodermal… CONTINUE READING

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