Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.

@article{Zhao2014UpregulationOT,
  title={Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance.},
  author={Ying Zhao and Flora Ling and Timothy M Griffin and Ting He and Rheal A Towner and Hong Ruan and Xiao-Hong Sun},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 42},
  pages={29112-22}
}
Id1, a helix-loop-helix (HLH) protein that inhibits the function of basic HLH E protein transcription factors in lymphoid cells, has been implicated in diet- and age-induced obesity by unknown mechanisms. Here we show that Id1-deficient mice are resistant to a high fat diet- and age-induced obesity, as revealed by reduced weight gain and body fat, increased lipid oxidation, attenuated hepatosteatosis, lower levels of lipid droplets in brown adipose tissue, and smaller white adipocytes after a… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Id proteins in development, cell cycle and cancer.

Trends in cell biology • 2003
View 5 Excerpts
Highly Influenced

Regulation of adipogen Id1 Deficiency Leads to Up-regulation of Sirt1 and PGC-1

B. M. Spiegelman
Banting Lecture • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…