Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved.

@article{Nikevi2008UpregulationOT,
  title={Up-regulation of the SOX3 gene expression by retinoic acid: characterization of the novel promoter-response element and the retinoid receptors involved.},
  author={Gordana Nik{\vc}evi{\'c} and Tijana Savi{\'c} and Nata{\vs}a Kova{\vc}evi{\'c}-Gruji{\vc}i{\'c} and Milena V. Stevanovi{\'c}},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 5},
  pages={1206-15}
}
Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates and it is implicated in the genetic cascades that direct brain formation. We have previously shown that early phases of differentiation and neural induction of NT2/D1 embryonal carcinoma cells by retinoic acid (RA) involve up-regulation of the SOX3 gene expression. Here, we present identification of a novel positive regulatory promoter element involved in RA-dependent activation of the SOX3 gene expression in… CONTINUE READING