Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease.

  title={Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease.},
  author={Tiziana Parrello and Giovanni Monteleone and Salvatore Cucchiara and Ivan Monteleone and Ladislava Sebkova and Patrizia Doldo and Francesco Luzza and Francesco Pallone},
  journal={Journal of immunology},
  volume={165 12},
Crohn' s disease (CD) is a chronic intestinal inflammatory disorder characterized by aberrant mucosal Th1 cell activation and production of IL-12, the major Th1-driving factor. The T cell response to IL-12 is dependent on the expression of a specific receptor composed of two subunits, termed IL-12Rbeta1 and IL-12Rbeta2. The content of IL-12Rbeta2, as measured at the mRNA level, is crucial in regulating Th1 differentiation. In this study we therefore investigated IL-12Rbeta2 RNA transcripts in… CONTINUE READING


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