Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine.

@article{Garnier2003UpregulationOR,
  title={Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine.},
  author={Martine J Garnier and Paola F Zaratin and Giovanna Ficalora and Maurizio Valente and Laura Fontanella and Man-hee Rhee and Kendall J Blumer and Mark A. Scheideler},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 3},
  pages={1299-306}
}
We hypothesized that the up-regulated expression of one or more members of the regulator of G protein signaling (RGS) family can cause an attenuation of signaling via Gi/Go-coupled opioid receptors, and thereby play a role in the development of hyperalgesia and accompanying insensitivity to morphine observed in animal models of neuropathic pain. Accordingly, we examined the mRNA expression of several RGS genes in a rat model of chronic neuropathic pain induced by partial ligation of the sciatic… CONTINUE READING
22 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Similar Papers

Loading similar papers…