Up-regulation of p2x2, p2x4 receptor and ischemic cell death: prevention by p2 antagonists

@article{Cavaliere2003UpregulationOP,
  title={Up-regulation of p2x2, p2x4 receptor and ischemic cell death: prevention by p2 antagonists},
  author={Fabio Cavaliere and Fulvio Florenzano and Anne Marie Sferra and Francesca R Fusco and Cinzia Volont{\'e}},
  journal={Neuroscience},
  year={2003},
  volume={120},
  pages={85-98}
}
In the present work we examined the involvement of selected P2X receptors for extracellular ATP in the onset of neuronal cell death caused by glucose/oxygen deprivation. The in vitro studies of organotypic cultures from hippocampus evidenced that P2X2 and P2X4 were up-regulated by glucose/oxygen deprivation. Moreover, we showed that ischemic conditions induced specific neuronal loss not only in hippocampal, but also in cortical and striatal organotypic cultures and the P2 receptor antagonists… CONTINUE READING
BETA

Topics from this paper.

Similar Papers

Loading similar papers…