Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

@article{Draisci1991UpregulationOO,
  title={Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation},
  author={Gaetano Draisci and Keith C. Kajander and Ronald Dubner and Gary J. Bennett and Michael J. Iadarola},
  journal={Brain Research},
  year={1991},
  volume={560},
  pages={186-192}
}
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158 Citations
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158 Citations

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Findings have important therapeutic implications because the pain of tissue and nerve damage can now be attacked at the site of injury where it is initiated and at central nervous system sites Where it is maintained.

The persistent pain transcriptome: identification of cells and molecules activated by hyperalgesia.

Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models

Enhancement of the antiallodynic and antinociceptive efficacy of spinal morphine by antisera to dynorphin A (1–13) or MK-801 in a nerve-ligation model of peripheral neuropathy

Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain

...

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