Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers.

@article{Brody2013UpregulationON,
  title={Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers.},
  author={Arthur L. Brody and Alexey G. Mukhin and Jaime La Charite and Karen Ta and Judah B. Farahi and Catherine A. Sugar and Michael S. Mamoun and Evan E Vellios and Meena M Archie and Maggie Kozman and Jonathan S. Phuong and Franca Arlorio and Mark A. Mandelkern},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 5},
  pages={
          957-66
        }
}
One-third of smokers primarily use menthol cigarettes and usage of these cigarettes leads to elevated serum nicotine levels and more difficulty quitting in standard treatment programmes. Previous brain imaging studies demonstrate that smoking (without regard to cigarette type) leads to up-regulation of β(2)*-containing nicotinic acetylcholine receptors (nAChRs). We sought to determine if menthol cigarette usage results in greater nAChR up-regulation than non-menthol cigarette usage. Altogether… CONTINUE READING