Up-regulation of myocardial connexin-43 in spontaneously hypertensive rats fed red palm oil is most likely implicated in its anti-arrhythmic effects.

@article{Baov2012UpregulationOM,
  title={Up-regulation of myocardial connexin-43 in spontaneously hypertensive rats fed red palm oil is most likely implicated in its anti-arrhythmic effects.},
  author={Barbara Szeiffov{\'a} Ba{\vc}ov{\'a} and J Radosinska and Csilla Viczenczov{\'a} and Vladim{\'i}r Knezl and Victor A. Dosenko and Tamara Egan Beňov{\'a} and Jana N{\'a}varov{\'a} and Eva Gonçalvesov{\'a} and Jacques van Rooyen and Peter Weismann and Jan SlezakJ. Slezak and Narcis Tribulova},
  journal={Canadian journal of physiology and pharmacology},
  year={2012},
  volume={90 9},
  pages={
          1235-45
        }
}
The purpose of this study was to test our hypothesis that red palm oil (RPO) intake may affect abnormalities of myocardial connexin-43 (Cx43) and protein kinase Cε (PKCε) signaling, and consequently the propensity of the spontaneously hypertensive rat heart (SHR) heart to arrhythmias. SHR and Wistar-Kyoto (WKY) rats fed a standard rat chow plus red palm oil (200 µL/day) for 5 weeks were compared with untreated rats. Cytosolic but not particulate PKCε expression as well as Cx43-mRNA, total Cx43… CONTINUE READING
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