Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer

@article{Smith1999UpregulationOM,
  title={Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer},
  author={Kathryn J Smith and Thi Dung Bui and Richard Poulsom and Loukas Kaklamanis and Gareth R Williams and A. L. Harris},
  journal={British Journal of Cancer},
  year={1999},
  volume={81},
  pages={496 - 502}
}
SummaryDefects in the APC-β-catenin pathway are common in colon cancer. We investigated whether aberrant regulation of upstream ligands stimulating this pathway occur in colon cancer. Using RNAase protection analysis, six out of eight wnt genes were expressed in 14 matched cases of normal, adenomatous and malignant colorectal tissues. Wnt 2 and wnt 5a were significantly up-regulated in the progression from normal through adenoma to carcinoma. Transcripts for wnts 4, 7b, 10b and 13, but not wnt… CONTINUE READING

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