Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma

@article{Zhang2017UpregulationOL,
  title={Up-regulation of long non-coding RNA SPRY4-IT1 promotes tumor cell migration and invasion in lung adenocarcinoma},
  author={X. Zhang and Q. Chi and Z. Zhao},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={51058 - 51065}
}
Long non-coding RNAs (lncRNAs) play important role in a variety of biological processes, and are tightly associated with tumorigenesis and cancer prognosis. However, the potential power of lncRNA signatures in predicting survival of patients with lung adenocarcinoma (LUAD) has not been investigated. Here, we identified a four-lncRNA signature (SPRY4-IT1, LINC00941,GPR158-AS1 and KCNK15-AS1) displaying prognostic values for LUAD using The Cancer Genome Atlas (TCGA) dataset. Based on the four… Expand
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From biomarkers to therapeutic targets—the promises and perils of long non-coding RNAs in cancer
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