Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.

@article{Li2011UpregulationOK,
  title={Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.},
  author={Na Li and David J. Bates and Jin An and Derek A Terry and Eugenia Wang},
  journal={Neurobiology of aging},
  year={2011},
  volume={32 5},
  pages={944-55}
}
Although significant advances have been made in the study of the molecular mechanisms controlling brain aging, post-transcriptional gene regulation in normal brain aging has yet to be explored. Our lab recently reported that predominant microRNA up-regulation is observed in liver during aging, with key microRNAs predicted to target detoxification genes. Here we examine the role of microRNA regulation in brain during the normal aging process. MicroRNA microarrays and global proteomic profiling… CONTINUE READING
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