Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.

@article{Lu2005UpRO,
  title={Up regulation of interleukin-8 expressions induced by mast cell tryptase via protease activated receptor-2 in endothelial cell line.},
  author={Chao Lu and Feng-di Zhao and Xiaobo Li and Lian-hua Yin},
  journal={Chinese medical journal},
  year={2005},
  volume={118 22},
  pages={1900-6}
}
BACKGROUND Protease activated receptor-2 is cleaved and activated by trypsin or mast cell tryptase and may play an important role in inflammation. However, it is unknown whether PAR-2 can mediate tryptase-induced inflammatory reaction. This study was conduct to investigate whether PAR-2 could be the activated by mast cell tryptase and medicated the tryptase induced interleukin-8 expression in endothelial cells. METHODS Protease activated receptor-2 expression was found in endothelial cell… CONTINUE READING

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