Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-α via type I interferon-dependent and -independent pathways

@article{Chairatvit2012UpregulationOI,
  title={Up-regulation of interferon-stimulated gene15 and its conjugates by tumor necrosis factor-α via type I interferon-dependent and -independent pathways},
  author={Kongthawat Chairatvit and Ariyaphong Wongnoppavich and Sirinthip Choonate},
  journal={Molecular and Cellular Biochemistry},
  year={2012},
  volume={368},
  pages={195-201}
}
Interferon-stimulated gene15 (ISG15) is the first characterized ubiquitin-like protein, which is strongly induced by type I interferons (IFN-α/β), bacterial endotoxin, and cellular stress. Up-regulation of ISG15 is observed in several cancer cell types and is associated with cancer progression. As many cytokines can influence all stages of tumorigenesis, the elevated expression of ISG15 system may be regulated in cancer cells by inflammatory cytokines. In this study, we showed that TNF-α, but… CONTINUE READING
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