Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer.

@article{Chiang2008UpregulationOI,
  title={Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer.},
  author={Shang-Lun Chiang and Ping-Ho Chen and Chien-Hung Lee and A. Ko and Ka-Wo Lee and Ying-Chu Lin and Pei-Shan Ho and H. Tu and Deng-Chyang Wu and T. Shieh and Ying-Chin Ko},
  journal={Cancer research},
  year={2008},
  volume={68 20},
  pages={
          8489-98
        }
}
  • Shang-Lun Chiang, Ping-Ho Chen, +8 authors Ying-Chin Ko
  • Published 2008
  • Medicine
  • Cancer research
Because the mRNA expression of cyclooxygenase-2 (COX-2) is up-regulated by arecoline in human gingival fibroblasts, as shown in our previous study, we further investigated the mRNA expression level of COX-2 and its upstream effectors in three oral epithelial carcinoma cell lines (KB, SAS, and Ca9-22) by using areca nut extract (ANE) and saliva-reacted ANE (sANE). A case-control study of 377 oral squamous cell carcinoma (OSCC) patients and 442 controls was conducted to evaluate the gene… Expand
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