Up-regulation of inducible nitric oxide synthase in fibroblasts parallels the onset and progression of fibrosis in an experimental model of post-transplant obliterative airway disease.

@article{Romanska2000UpregulationOI,
  title={Up-regulation of inducible nitric oxide synthase in fibroblasts parallels the onset and progression of fibrosis in an experimental model of post-transplant obliterative airway disease.},
  author={Hanna Romanska and Tuija S. Ikonen and Anne E. Bishop and Randall E. Morris and Julia M P Polak},
  journal={The Journal of pathology},
  year={2000},
  volume={191 1},
  pages={71-7}
}
The main cause of mortality following lung transplantation is chronic rejection, manifesting morphologically as obliterative bronchiolitis (OB). It has been suggested that damage to the respiratory epithelium initiates proliferation of mesenchymal cells, leading to dense collagenous scarring in small airways. Inducible nitric oxide synthase (iNOS) is strongly expressed in the damaged epithelium in human OB, along with high levels of peroxynitrite, suggesting that endogenous NO mediates the… CONTINUE READING

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