Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

@article{Krieg2000UpregulationOH,
  title={Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function},
  author={Marion Krieg and Richard Weber Haas and Hiltrud Brauch and Till Acker and Ingo Flamme and Karl Heinz Plate},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={5435-5443}
}
Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix–loop–helix PAS family, composed of α and β subunits. HIF-1α shares 48 per cent identity with the recently identified HIF-2α protein that is also stimulated by hypoxia. In a previous study of hemangioblastomas, the most frequent… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 136 CITATIONS

FILTER CITATIONS BY YEAR

1969
2019

CITATION STATISTICS

  • 9 Highly Influenced Citations

  • Averaged 4 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 14 REFERENCES

Am

  • I Flamme, M Krieg, KH. Plate
  • J. Pathol., 153, 25 ± 29.
  • 1998
Highly Influential
9 Excerpts

Proc

  • GL Wang, Jiang B-H, AE Rue, Semenza GL.
  • Natl. Acad. Sci. USA, 92, 5510 ± 5514.
  • 1995
Highly Influential
24 Excerpts

J

  • LE Huang, Z Arany, DM Livingston, HF. Bunn
  • Biol. Chem., 271, 32253 ± 32259.
  • 1996
Highly Influential
5 Excerpts

J

  • S Salceda, J. Caro
  • Biol. Chem., 272, 22642 ± 22647.
  • 1999

J

  • CA Trash-Bingham, Tartof KD.
  • Nat. Cancer Institute, 91, 143 ± 151.
  • 1999

J

  • Semenza GL.
  • Lab. Clin Med., 131, 207 ± 214.
  • 1998

Mol

  • KM Lonergan, O Iliopoulos, +4 authors WG. Kaelin
  • Cell. Biol., 18, 732 ± 741.
  • 1998

Proc

  • LE Huang, J Gu, M Schau, HF. Bunn
  • Natl. Acad. Sci. USA, 95, 7987 ± 7992.
  • 1998

Biol

  • RH Wenger, M. Gassmann
  • Chem., 378, 609 ± 616.
  • 1997
3 Excerpts

Proc

  • M Ema, S Taya, N Yokotani, K Sogawa, Y Matsuda, Y. Fujii-Kuriyama
  • Natl. Acad. Sci. USA, 94, 4273 ± 4278.
  • 1997

Similar Papers

Loading similar papers…