Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis.

@article{Zhong2004UpregulationOH,
  title={Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis.},
  author={Hua Zhong and Gregg L Semenza and Jonathan W. Simons and Angelo M De Marzo},
  journal={Cancer detection and prevention},
  year={2004},
  volume={28 2},
  pages={88-93}
}
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding glucose transporters, glycolytic enzymes, and vascular endothelial growth factor (VEGF). HIF-1alpha is a major subunit of HIF-1 heterodimer. In this study, an immunohistochemical analysis of HIF-1alpha was focused on clinical specimens containing high-grade prostate intraepithelial neoplasia lesions since high-grade prostate intraepithelial neoplasia is considered the precursor of a majority of invasive prostate… CONTINUE READING
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