Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.

@article{Kakizaki2008UpregulationOH,
  title={Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.},
  author={Ikuko Kakizaki and Naoki Itano and Koji Kimata and Katsumi Hanada and Atsushi Kon and Masanori Yamaguchi and Teruno Takahashi and Keiichi Takagaki},
  journal={Archives of biochemistry and biophysics},
  year={2008},
  volume={471 1},
  pages={
          85-93
        }
}
Hyaluronan controls keratinocyte proliferation and regeneration. We examined effect of UV on the expression of hyaluronan synthases (HASs) and hyaluronidases in cultured normal human newborn foreskin epidermal keratinocytes, NHEK(F). HAS3 mRNA was expressed predominantly and HAS2 mRNA expressed in lesser amounts and both were up-regulated after a single irradiation with moderate UVB but hyaluronidases was unchanged. Increased accumulation of hyaluronan in the culture medium mirrored the UVB… CONTINUE READING
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