Up-regulation of hepatocyte growth factor caused by an over-expression of transforming growth factor beta, in the rat model of fulminant hepatic failure.

@article{Nozato2003UpregulationOH,
  title={Up-regulation of hepatocyte growth factor caused by an over-expression of transforming growth factor beta, in the rat model of fulminant hepatic failure.},
  author={Eiji Nozato and Masayuki Shiraishi and Tadashi Nishimaki},
  journal={The Journal of surgical research},
  year={2003},
  volume={115 2},
  pages={226-34}
}
BACKGROUND The role of transforming growth factor beta (TGF-beta), a potent regulator of cellular growth, was investigated in the rat model of fulminant hepatic failure (FHF). MATERIALS AND METHODS The rat FHF model was created by a combination of a 68% partial hepatectomy (PH) and 7% of necrosis (each n = 25 in Groups 1, 2 and 3). Adenovirus mediated gene transfer of mature human TGF-beta1 gene was performed by the systemic injection of AxCAhTGFb1 (1 x 10(9) pfu) in Group 1, 3 days before… CONTINUE READING

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An excessive expression of TGF - beta1 in Group 1 resulted in an inhibition of hepatocyte proliferation ( 24 - 48 h after FHF ) and gaining of liver weight ( 24 - 48 h ) , increased expression of HGF in liver tissue ( 24 h ) , and decreased expression of TGF - alpha ( 24 h ) , compared to those in control Groups 2 and 3 .
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