Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae

@article{Terashima2000UpregulationOG,
  title={Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae},
  author={Hiromichi Terashima and N. Yabuki and Mikio Arisawa and Kenji Hamada and Kunio Kitada},
  journal={Molecular and General Genetics MGG},
  year={2000},
  volume={264},
  pages={64-74}
}
FKS1 and FKS2 encode alternative catalytic subunits of the glucan synthases that are responsible for synthesis of β-1,3-glucan in the Saccharomyces cerevisiae cell wall. Disruption of FKS1 reduces the glucan content of the cell wall, increases chitin content and activates the expression of CWP1, which encodes a glycosylphosphatidylinositol (GPI)-dependent cell wall protein. These cellular responses have been regarded as compensating for cell wall damage in order to maintain cell wall integrity… CONTINUE READING

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