Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression.

@article{Kostianovsky2007UpregulationOG,
  title={Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression.},
  author={Alex M. Kostianovsky and Lisa M. Maier and Clare Baecher-Allan and Ana Carrizossa Anderson and David E. Anderson},
  journal={Journal of immunology},
  year={2007},
  volume={178 10},
  pages={6158-63}
}
A growing body of literature indicates that the Notch pathway can influence the activation and differentiation of peripheral murine T cells, though comparatively little is known about the effects of Notch signaling in human T cells. In the present report we demonstrate that Jagged-1-induced Notch signaling (using immobilized Jagged-1 fusion protein) during… CONTINUE READING