Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP).

@article{Inokuchi1997UpregulationOG,
  title={Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP).},
  author={Jin-ichi Inokuchi and Akira Mizutani and Masayuki Jimbo and Seigou Usuki and Kiwamu Yamagishi and Hidenori Mochizuki and Kenichiro Muramoto and Kazuto Kobayashi and Yukiko Kuroda and Kouichi Iwasaki and Yusuke Ohgami and Michihiro Fujiwara},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={237 3},
  pages={595-600}
}
To address the role of brain gangliosides in synaptic activity, the ceramide analogs, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and its enantiomer, L-PDMP, were used to inhibit and stimulate ganglioside biosynthesis in cultured cortical neurons. Prolonged treatment with both PDMP isomers exhibited opposite effects on functional synapse formation measured by spontaneous synchronized oscillatory activity of intracellular Ca2+ between the neurons: suppression by D-PDMP and… CONTINUE READING

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