Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis.

@article{Ding2006UpregulationOF,
  title={Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis.},
  author={Ziqiang Ding and Song Hui Jia and John C. Marshall and Gregory P Downey and Thomas K Waddell},
  journal={Critical care medicine},
  year={2006},
  volume={34 12},
  pages={3011-7}
}
OBJECTIVE Lymphocyte dysfunction has been documented in sepsis, and evidence suggests that lymphocyte infiltration contributes to tissue injury. The purpose of this study was to examine chemokine receptor expression and function in lymphocytes from septic patients and healthy donors. DESIGN Observational study of septic patients and laboratory investigation of normal controls. SETTING Tertiary care intensive care unit. PATIENTS AND SUBJECTS Nine critically ill patients fulfilling criteria… CONTINUE READING