Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.

@article{Roy2006UpregulationOE,
  title={Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.},
  author={Anju Anne Roy and Caroline Nunn and Hong Ming and Min-Xu Zou and Josef M. Penninger and Lorrie A. Kirshenbaum and Scott J. Dixon and Peter Chidiac},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 43},
  pages={
          32684-93
        }
}
Regulator of G protein signaling (RGS) proteins limit G protein signals. In this study, we investigated the role of RGS2 in the control of G protein signaling cascades in osteoblasts, the cells responsible for bone formation. Expression of RGS2 was up-regulated in primary cultures of mouse calvarial osteoblasts by parathyroid hormone-related peptide (PTHrP)-(1-34), which stimulates G(s) signaling. RGS2 was also up-regulated by extracellular ATP, which selectively activates G(q), as well as by… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

by gest on Sptem er 1, 2017 hp://w w w .jb.org/ D

C. G. Bellows, J. N. Heersche
  • J. Bone Miner. Res
  • 2001
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

hp://w w w .jb.org/ D

Y. Wu, R. Kumar
  • J. Bone Miner. Metab. 15,
  • 2000
VIEW 1 EXCERPT