Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation.

@article{Herrick1997UpregulationOE,
  title={Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation.},
  author={Sarah E Herrick and Gillian Ashcroft and Grenham W. Ireland and Michael Arthur Horan and Charles C. N. McCollum and Mark W. J. Ferguson},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1997},
  volume={77 3},
  pages={281-8}
}
Chronic wound healing states are often associated with aging, and despite the increased number of aged patients with nonhealing wounds, controversy still exists concerning the effects of age on wound repair. Our previous work showed that in both venous ulcers in humans and acute wounds in aged animals, fibronectin, an early component in granulation tissue… CONTINUE READING