Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line.

@article{Bek2003UpregulationOE,
  title={Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line.},
  author={Martin Johannes Bek and Hans Christian Reinhardt and K Fischer and Jochen R. Hirsch and Charlotte Hupfer and Eileen Dayal and Hermann J. Pavenst{\"a}dt},
  journal={Journal of immunology},
  year={2003},
  volume={170 2},
  pages={931-40}
}
The CXCR3 chemokine receptor, a member of the CXCR family, has been linked to a pathological role in autoimmune disease, inflammatory disease, allograft rejection, and ischemia. In the kidney, expression of the CXCR3 receptor and its ligands is up-regulated in states of glomerulonephritis and in allograft rejection, but little is known about the expression… CONTINUE READING