Up-regulation of dopamine D2 receptor mRNA in rat striatum by chronic neuroleptic treatment.

@article{Rogue1991UpregulationOD,
  title={Up-regulation of dopamine D2 receptor mRNA in rat striatum by chronic neuroleptic treatment.},
  author={Patrick J Rogue and Andr{\'e} Hanauer and Jean Zwiller and Anant Narain Malviya and Guy Vincendon},
  journal={European journal of pharmacology},
  year={1991},
  volume={207 2},
  pages={165-8}
}
The effect of prolonged administration of antagonists on rat striatal dopamine D2 receptor binding and mRNA content was examined. Both haloperidol (2 and 4 mg/kg) and sulpiride (10 mg/kg) induced a significant rise in total D2 and D2(444) mRNA level and in Bmax. Regulation of messenger RNA accumulation is thus an important determinant of dopamine D2 receptor density.