Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.

@article{Chiosea2006UpregulationOD,
  title={Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.},
  author={Simion I Chiosea and Elena Jelezcova and Uma Chandran and Marie B Acquafondata and T. J. McHale and Robert William Sobol and Rajiv Dhir},
  journal={The American journal of pathology},
  year={2006},
  volume={169 5},
  pages={1812-20}
}
MicroRNAs are small noncoding 18- to 24-nt RNAs that are predicted to regulate expression of as many as 30% of protein-encoding genes. In prostate adenocarcinoma, 39 microRNAs are up-regulated, and six microRNAs are down-regulated. Production and function of microRNA requires coordinated processing by proteins of the microRNA machinery. Dicer, an RNase III endonuclease, is an essential component of the microRNA machinery. From a gene array analysis of 16 normal prostate tissue samples, 64 organ… CONTINUE READING