Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.

@article{Hendrickx2003UpregulationOC,
  title={Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells.},
  author={Nico Hendrickx and C{\'e}dric Volanti and Ugo Moens and Ole Morten Seternes and Peter A. M. de Witte and Jackie R. Vandenheede and Jacques Piette and Patrizia Agostinis},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={52231-9}
}
Photodynamic Therapy (PDT) is an approved anticancer therapy that kills cancer cells by the photochemical generation of reactive oxygen species following absorption of visible light by a photosensitizer, which selectively accumulates in tumors. We report that hypericin-mediated PDT of human cancer cells leads to up-regulation of the inducible cyclooxygenase-2 (COX-2) enzyme and the subsequent release of PGE2. Dissection of the signaling pathways involved revealed that the selective activation… CONTINUE READING

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