Corpus ID: 20196284

Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.

@article{Park2006UpregulationOC,
  title={Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.},
  author={Sung Gyoo Park and Chan Chung and Hang Kang and Ji-yeon Kim and G. Jung},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 42},
  pages={
          31770-7
        }
}
Cyclin D1 is frequently overexpressed in hepatocellular carcinoma (HCC) exhibiting increased malignant phenotypes. It has also been known that the hepatitis Bx (HBx) protein is strongly associated with HCC development and progression. Although overexpression of both proteins is related to HCC, the relationship between the two has not been well studied. Here we show that HBx up-regulates cyclin D1 and that this process is mediated by the NF-kappaB2(p52)/BCL-3 complex. Our experiments indicate… Expand
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