Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina.

@article{Chen2008UpregulationOC,
  title={Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina.},
  author={Mei Chen and Elizabeth Muckersie and Marie Robertson and John V. Forrester and Heping Xu},
  journal={Experimental eye research},
  year={2008},
  volume={87 6},
  pages={543-50}
}
Complement activation is involved in the pathogenesis of age-related macular degeneration. How complement is activated in the retina is not known. Previously we have shown that complement factor H (CFH) is constitutively expressed by retinal pigment epithelial (RPE) cells and the production of CFH is negatively regulated by inflammatory cytokines and oxidative insults. Here we investigated the production and regulation of complement factor B (CFB) in RPE cells. Immunohistochemistry showed that… CONTINUE READING

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