Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors.

Abstract

Photodynamic therapy (PDT) using the silicon phthalocyanine photo-sensitizer Pc 4 is an oxidative stress associated with the induction of apoptosis in many cancer cells in vitro and in vivo. The mechanisms of PDT-induced tumor cell killing leading to apoptosis are incompletely understood. Clusterin, a widely expressed glycoprotein, is induced in tissues… (More)

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@article{Kalka2000UpregulationOC, title={Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors.}, author={Katrin Kalka and Norazah Ahmad and Theodore P Criswell and David A. Boothman and Hussnain Mukhtar}, journal={Cancer research}, year={2000}, volume={60 21}, pages={5984-7} }