Up-regulation of cartilage oligomeric matrix protein gene expression by insulin-like growth factor-I revealed by real-time reverse transcription-polymerase chain reaction.

@article{Tian2006UpregulationOC,
  title={Up-regulation of cartilage oligomeric matrix protein gene expression by insulin-like growth factor-I revealed by real-time reverse transcription-polymerase chain reaction.},
  author={Hua Tian and Ioannis Stogiannidis},
  journal={Acta biochimica et biophysica Sinica},
  year={2006},
  volume={38 10},
  pages={
          677-82
        }
}
Cartilage oligomeric matrix protein (COMP) strengthens cartilage by binding to type II and type IX collagen-forming bridges between collagen fibrils. It was hypothesized that perhaps one or more anabolic growth factors such as insulin-like growth factor-I (IGF-I), fibroblast growth factor-1 (FGF-1) or platelet derived growth factor-BB (PDGF-BB) increase COMP gene expression. Their effects on primary human chondrocytes and the chondrogenic cell line ATDC5 were studied using real time reverse… CONTINUE READING