Up-regulation of cardiac nitric oxide synthase 1-derived nitric oxide after myocardial infarction in senescent rats.

@article{Damy2003UpregulationOC,
  title={Up-regulation of cardiac nitric oxide synthase 1-derived nitric oxide after myocardial infarction in senescent rats.},
  author={Thibaud Damy and Philippe Ratajczak and Estelle Robidel and Jennifer K. Bendall and Patricia Olivi{\'e}ro and Jorge Boczkowski and Talin Ebrahimian and Françoise Marotte and Jane-Lise Samuel and Christophe Heymes},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 13},
  pages={1934-6}
}
Nitric oxide (NO) has been implicated in the development of heart failure, although the source, significance, and functional role of the different NO synthase (NOS) isoforms in this pathology are controversial. The presence of a neuronal-type NOS isoform (NOS1) in the cardiac sarcoplasmic reticulum has been recently discovered, leading to the hypothesis that NOS1-derived NO may notably alter myocardial inotropy. However, the regulation and role(s) of NOS1 in cardiac diseases remain to be… CONTINUE READING

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