Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

@article{Clerk2002UpregulationOC,
  title={Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.},
  author={Angela Clerk and Timothy J Kemp and Joanne G Harrison and A. Mullen and Paul J Barton and Peter H. Sugden},
  journal={The Biochemical journal},
  year={2002},
  volume={368 Pt 1},
  pages={101-10}
}
Cardiac hypertrophy, an important adaptational response, is associated with up-regulation of the immediate early gene, c- jun, which encodes the c-Jun transcription factor. c-Jun may feed back to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein kinases (MAPKs) phosphorylate c-Jun(Ser-63/73) to increase its transactivating activity, JNKs are thought to be the principal factors involved in c- jun up-regulation. Hypertrophy in… CONTINUE READING
19 Extracted Citations
54 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 19 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 54 references

The MEK 1 - ERK 1 / 2 signaling pathway promotes compensated hypertrophy in transgenic mice

  • O. F. Bueno, L. J. De Windt, +7 authors C.-F. Peng
  • EMBO J .
  • 2000

Similar Papers

Loading similar papers…