Up-regulation of antioxidant enzymes and coenzyme Q(10) in a human oral cancer cell line with acquired bleomycin resistance.

@article{Yen2011UpregulationOA,
  title={Up-regulation of antioxidant enzymes and coenzyme Q(10) in a human oral cancer cell line with acquired bleomycin resistance.},
  author={Hsiu-Chuan Yen and Shijun Li and Hideyuki J. Majima and Yu-Hsiang Huang and Chiu-Ping Chen and Chia-chi Liu and Ya-Chi Tu and Chih-Wei Chen},
  journal={Free radical research},
  year={2011},
  volume={45 6},
  pages={707-16}
}
Bleomycin (BLM) is an anti-cancer drug that can induce formation of reactive oxygen species (ROS). To investigate the association between up-regulation of antioxidant enzymes and coenzyme Q(10) (CoQ(10)) in acquired BLM resistance, one BLM-resistant clone, SBLM24 clone, was selected from a human oral cancer cell line, SCC61 clone. The BLM resistance of SBLM24 clone relative to a sub-clone of SCC61b cells was confirmed by analysis of clonogenic ability and cell cycle arrest. CoQ(10) levels and… CONTINUE READING

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