Up-regulation of a fibroblast growth factor binding protein in children with renal diseases.

@article{Liu2001UpregulationOA,
  title={Up-regulation of a fibroblast growth factor binding protein in children with renal diseases.},
  author={Xiao-Yuan Liu and Achim Aigner and Anton Wellstein and Patricio E. Ray},
  journal={Kidney international},
  year={2001},
  volume={59 5},
  pages={1717-28}
}
BACKGROUND Basic fibroblast growth factor (bFGF) is an angiogenic growth factor that is involved in renal growth and the pathogenesis of renal diseases. We have detected high levels of bFGF accumulated in the kidney of HIV-transgenic mice and in children with HIV-associated renal diseases and the hemolytic uremic syndrome (HUS). However, the mechanism modulating the activity of bFGF under these circumstances is poorly understood. We carried out experiments to determine whether a secreted… CONTINUE READING
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