Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells

@article{Cui2014UpregulationOU,
  title={Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells},
  author={Lei Cui and Jixiang Chen and Qing Zhang and Xuqing Wang and Jianguo Qu and Jianxin Zhang and Shenchun Dang},
  journal={Molecular and Cellular Biochemistry},
  year={2014},
  volume={400},
  pages={223-232}
}
Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) has been reported as a marker for the differential diagnosis of pancreatic cancer and chronic pancreatitis. However, the expression pattern and biological functions of UHRF1 in the progression of pancreatic cancer are not fully understood. In this study, it was found that the expression of UHRF1 was significantly up-regulated in pancreatic cancer samples compared to their adjacent normal tissues. Meanwhile, the expression of UHRF1 was… CONTINUE READING
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Mutant KRAS is a druggable target for pancreatic cancer.

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