Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells.

@article{Gonzalez2009UpregulationOS,
  title={Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells.},
  author={Maria Elizabeth Gonzalez and Olga Makarova and Esther A. Peterson and Lisa M. Privette and Elizabeth M. Petty},
  journal={Cellular signalling},
  year={2009},
  volume={21 4},
  pages={477-87}
}
SEPT9_v1, the largest transcript of the septin gene family member, SEPT9, encodes a septin isoform implicated in the tumorigenic transformation of mammary epithelial cells. High levels of SEPT9_v1 expression also have been observed in both breast cancer cell lines, primary breast cancers as well as other solid tumor malignancies. We found a novel interaction between SEPT9_v1 and the c-Jun-N-terminal kinase (JNK), a mitogen-activated protein kinase important in cellular stress responses, cell… CONTINUE READING