Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain.

@article{Pedersen2006UpregulationOP,
  title={Up-regulation of PK11195 binding in areas of axonal degeneration coincides with early microglial activation in mouse brain.},
  author={Mads D Pedersen and Luciano Minuzzi and Martin Wirenfeldt and Michael Meldgaard and Carina Slidsborg and Paul Cumming and Bente Finsen},
  journal={The European journal of neuroscience},
  year={2006},
  volume={24 4},
  pages={991-1000}
}
Increased binding of the peripheral benzodiazepine binding site (PBBS) ligand [(3)H]PK11195 in the central nervous system of patients suffering from acute and chronic neuropathology has been associated with reactive microgliosis. However, it remains uncertain which stages of microglial activation occur in conjunction with the increased [(3)H]PK11195 binding. We used quantitative autoradiography for [(3)H]PK11195 and quantitative polymerase chain reaction for PBBS mRNA and markers of early and… CONTINUE READING