Up-regulation of P-glycoprotein is involved in the increased paclitaxel resistance in human esophageal cancer radioresistant cells.

@article{Wang2012UpregulationOP,
  title={Up-regulation of P-glycoprotein is involved in the increased paclitaxel resistance in human esophageal cancer radioresistant cells.},
  author={Yan Jun Wang and Qunfang Chen and Shu Jin and Weiping Deng and Shengbao Li and Qiang Tong and Yuezhou Chen},
  journal={Scandinavian journal of gastroenterology},
  year={2012},
  volume={47 7},
  pages={802-8}
}
OBJECTIVE Development of drug and radiation resistance is one of the major causes of cancer treatment failure with chemoradiotherapy. Whether radiotherapy affects drugs resistance in esophageal cancer cells remain to be determined. The purpose of the study was to investigate the change of drug-sensitivity and P-glycoprotein (P-gp) expression in ionization radiation-induced human esophageal cancer radioresistant cells. MATERIALS AND METHODS Radioresistant cells were established by means of… CONTINUE READING

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