Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels.

@article{Boyiadzis2008UpregulationON,
  title={Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels.},
  author={Michael Boyiadzis and Sarfraz Memon and Jesse Carson and Kenton Allen and Miroslaw J Szczepanski and Barbara A. Vance and Robert D. Bradley Paul R. Krausman Nancy E. McIntyre Acce Dean and Michael R. Bishop and Ronald E Gress and Frances T Hakim},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2008},
  volume={14 3},
  pages={290-300}
}
Because natural killer (NK) cells can be potent anti-tumor effectors after allogeneic stem cell transplantation, we investigated NK reconstitution and receptor expression in patients undergoing allogeneic hematopoietic stem cell transplantation, focusing on the activating receptors that trigger anti-tumor responses. We determined that NK levels in the peri-transplant period were inversely proportional to the dramatic rise and fall in plasma levels of the NK homeostatic cytokine IL-15, which… CONTINUE READING