Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.

  title={Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis.},
  author={Dae Hoon Kim and Ho-Suk Chu and Jin Young Lee and Soon Jae Hwang and Sang Hag Lee and Heung-Man Lee},
  journal={Archives of otolaryngology--head & neck surgery},
  volume={130 6},
BACKGROUND Excess mucus production and hypersecretion characterize upper airway diseases. The primary mechanisms leading to mucus hypersecretion in chronic rhinosinus inflammation are not well understood. Mucus hypersecretion is commonly accompanied by goblet cell and submucosal gland cell hyperplasia. It is important to identify which mucin gene messenger RNAs (mRNAs) are expressed in the sinus mucosa. OBJECTIVES To investigate the expression of MUC5AC and MUC5B mRNAs and localization of… CONTINUE READING
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