Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway

@article{Wang2015UpregulationOI,
  title={Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway},
  author={Hong-Wei Wang and Hai-li Gao and Xiao-xia Wei and Xinhong Wang},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={407},
  pages={135-142}
}
Hepatitis B virus (HBV) replicates noncytopathically in hepatocytes, but HBV or proteins encoded by HBV genome could induce cytokines, chemokines expression by hepatocytes.IL-12 is a typical proinflammatory cytokine that plays a critical role in host defense against pathogens, including the HBV. However, the role of IL-12 in chronic hepatitis B (CHB… CONTINUE READING