Up-regulation of GABAB Receptor Signaling by Constitutive Assembly with the K+ Channel Tetramerization Domain-containing Protein 12 (KCTD12)*

@inproceedings{Ivankova2013UpregulationOG,
  title={Up-regulation of GABAB Receptor Signaling by Constitutive Assembly with the K+ Channel Tetramerization Domain-containing Protein 12 (KCTD12)*},
  author={Klara Ivankova and Rostislav Turecek and Thorsten Fritzius and Riad Seddik and Laurent Pr{\'e}zeau and La{\"e}titia Comps-Agrar and Jean-Philippe Pin and Bernd Fakler and Val{\'e}rie Besseyrias and Martin Gassmann and Bernhard Bettler},
  booktitle={The Journal of biological chemistry},
  year={2013}
}
GABA(B) receptors are the G-protein coupled receptors (GPCRs) for GABA, the main inhibitory neurotransmitter in the central nervous system. Native GABA(B) receptors comprise principle and auxiliary subunits that regulate receptor properties in distinct ways. The principle subunits GABA(B1a), GABA(B1b), and GABA(B2) form fully functional heteromeric GABA(B(1a,2)) and GABA(B(1b,2)) receptors. Principal subunits regulate forward trafficking of the receptors from the endoplasmic reticulum to the… CONTINUE READING
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Sushi domains confer distinct trafficking profiles on GABAB receptors.

Proceedings of the National Academy of Sciences of the United States of America • 2012

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